A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses

The entorhinal cortex (EC) is one of the most vulnerable brain regions that is attacked during the early stage of Alzheimer’s disease (AD). Here, we report that the synaptic terminals of pyramidal neurons in the EC layer II (ECII(PN)) directly innervate CA1 parvalbumin (PV) neurons (CA1(PV)) and are...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Yang, X, Yao, C, Tian, T, Li, X, Yan, H, Wu, J, Li, H, Pei, L, Liu, D, Tian, Q, Zhu, L-Q, Lu, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794875/
https://ncbi.nlm.nih.gov/pubmed/27671476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.151
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