Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses

Choline acetyltransferase neurons in the vertical diagonal band of Broca (vChATs) degenerate in the early stage of Alzheimer’s disease (AD). Here, we report that vChATs directly innervate newly generated immature neurons (NGIs) in the dorsal hippocampus (dNGIs) of adult mice and regulate both the dN...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhu, Houze, Yan, Huanhuan, Tang, Na, Li, Xinyan, Pang, Pei, Li, Hao, Chen, Wenting, Guo, Yu, Shu, Shu, Cai, You, Pei, Lei, Liu, Dan, Luo, Min-Hua, Man, Hengye, Tian, Qing, Mu, Yangling, Zhu, Ling-Qiang, Lu, Youming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698429/
https://ncbi.nlm.nih.gov/pubmed/29162816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01943-0
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