Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence

To study the influenza virus determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012 [QT1480]) and 2013 (A/duck/Vietnam/QT1728/2013 [QT1728]) and found that the activity of their polymerase complexes d...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Zhong, Gongxun, Le, Mai Quynh, Lopes, Tiago J. S., Halfmann, Peter, Hatta, Masato, Fan, Shufang, Neumann, Gabriele, Kawaoka, Yoshihiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790930/
https://ncbi.nlm.nih.gov/pubmed/29212927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01557-17
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