Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence

To study the influenza virus determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012 [QT1480]) and 2013 (A/duck/Vietnam/QT1728/2013 [QT1728]) and found that the activity of their polymerase complexes d...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Zhong, Gongxun, Le, Mai Quynh, Lopes, Tiago J. S., Halfmann, Peter, Hatta, Masato, Fan, Shufang, Neumann, Gabriele, Kawaoka, Yoshihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790930/
https://ncbi.nlm.nih.gov/pubmed/29212927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01557-17
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