Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence

To study the influenza virus determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012 [QT1480]) and 2013 (A/duck/Vietnam/QT1728/2013 [QT1728]) and found that the activity of their polymerase complexes d...

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Bibliographic Details
Published in:J Virol
Main Authors: Zhong, Gongxun, Le, Mai Quynh, Lopes, Tiago J. S., Halfmann, Peter, Hatta, Masato, Fan, Shufang, Neumann, Gabriele, Kawaoka, Yoshihiro
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790930/
https://ncbi.nlm.nih.gov/pubmed/29212927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01557-17
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