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Amino Acid Changes in the Influenza A Virus PA Protein That Attenuate Avian H5N1 Viruses in Mammals

The influenza viral polymerase complex affects host tropism and pathogenicity. In particular, several amino acids in the PB2 polymerase subunit are essential for the efficient replication of avian influenza viruses in mammals. The PA polymerase subunit also contributes to host range and pathogenicit...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Fan, Shufang, Hatta, Masato, Kim, Jin Hyun, Le, Mai Quynh, Neumann, Gabriele, Kawaoka, Yoshihiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248959/
https://ncbi.nlm.nih.gov/pubmed/25231317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01081-14
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