Amino Acid Changes in the Influenza A Virus PA Protein That Attenuate Avian H5N1 Viruses in Mammals

The influenza viral polymerase complex affects host tropism and pathogenicity. In particular, several amino acids in the PB2 polymerase subunit are essential for the efficient replication of avian influenza viruses in mammals. The PA polymerase subunit also contributes to host range and pathogenicit...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Fan, Shufang, Hatta, Masato, Kim, Jin Hyun, Le, Mai Quynh, Neumann, Gabriele, Kawaoka, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248959/
https://ncbi.nlm.nih.gov/pubmed/25231317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01081-14
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