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Amino Acid Changes in the Influenza A Virus PA Protein That Attenuate Avian H5N1 Viruses in Mammals

The influenza viral polymerase complex affects host tropism and pathogenicity. In particular, several amino acids in the PB2 polymerase subunit are essential for the efficient replication of avian influenza viruses in mammals. The PA polymerase subunit also contributes to host range and pathogenicit...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Fan, Shufang, Hatta, Masato, Kim, Jin Hyun, Le, Mai Quynh, Neumann, Gabriele, Kawaoka, Yoshihiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248959/
https://ncbi.nlm.nih.gov/pubmed/25231317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01081-14
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