Amino Acid Changes in the Influenza A Virus PA Protein That Attenuate Avian H5N1 Viruses in Mammals

The influenza viral polymerase complex affects host tropism and pathogenicity. In particular, several amino acids in the PB2 polymerase subunit are essential for the efficient replication of avian influenza viruses in mammals. The PA polymerase subunit also contributes to host range and pathogenicit...

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Vydáno v:J Virol
Hlavní autoři: Fan, Shufang, Hatta, Masato, Kim, Jin Hyun, Le, Mai Quynh, Neumann, Gabriele, Kawaoka, Yoshihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248959/
https://ncbi.nlm.nih.gov/pubmed/25231317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01081-14
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