Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence

To study the influenza virus determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012 [QT1480]) and 2013 (A/duck/Vietnam/QT1728/2013 [QT1728]) and found that the activity of their polymerase complexes d...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zhong, Gongxun, Le, Mai Quynh, Lopes, Tiago J. S., Halfmann, Peter, Hatta, Masato, Fan, Shufang, Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790930/
https://ncbi.nlm.nih.gov/pubmed/29212927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01557-17
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