Piperine ameliorates SCA17 neuropathology by reducing ER stress

BACKGROUND: Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads to the misfolding of TBP and the preferential degeneration in the cerebellar P...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Guo, Jifeng, Cui, Yiting, Liu, Qiong, Yang, Yang, Li, Yujing, Weng, Ling, Tang, Beisha, Jin, Peng, Li, Xiao-Jiang, Yang, Su, Li, Shihua
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789626/
https://ncbi.nlm.nih.gov/pubmed/29378605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0236-x
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