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Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice

In polyglutamine (polyQ) diseases, large polyQ repeats cause juvenile cases with different symptoms than adult-onset patients, who carry smaller expanded polyQ repeats. The mechanisms behind the differential pathology mediated by different polyQ repeat lengths remain unknown. By studying knock-in mo...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Huang, Shanshan, Yang, Su, Guo, Jifeng, Yan, Sen, Gaertig, Marta A., Li, Shihua, Li, Xiao-Jiang
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598297/
https://ncbi.nlm.nih.gov/pubmed/26387956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.060
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