DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

BACKGROUND: Genetic predisposition and epigenetic alterations are both considered to contribute to sporadic neurodegenerative diseases (NDDs) such as Parkinson’s disease (PD). Since cell reprogramming and the generation of induced pluripotent stem cells (iPSCs) are themselves associated with major e...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Clin Epigenetics
Main Authors: de Boni, Laura, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789607/
https://ncbi.nlm.nih.gov/pubmed/29422978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0440-0
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