DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling

BACKGROUND: Genetic predisposition and epigenetic alterations are both considered to contribute to sporadic neurodegenerative diseases (NDDs) such as Parkinson’s disease (PD). Since cell reprogramming and the generation of induced pluripotent stem cells (iPSCs) are themselves associated with major e...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: de Boni, Laura, Gasparoni, Gilles, Haubenreich, Carolin, Tierling, Sascha, Schmitt, Ina, Peitz, Michael, Koch, Philipp, Walter, Jörn, Wüllner, Ullrich, Brüstle, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789607/
https://ncbi.nlm.nih.gov/pubmed/29422978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0440-0
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