Communication between N terminus and loop2 tunes Orai activation

Ca(2+) release-activated Ca(2+) (CRAC) channels constitute the major Ca(2+) entry pathway into the cell. They are fully reconstituted via intermembrane coupling of the Ca(2+)-selective Orai channel and the Ca(2+)-sensing protein STIM1. In addition to the Orai C terminus, the main coupling site for S...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fahrner, Marc, Pandey, Saurabh K., Muik, Martin, Traxler, Lukas, Butorac, Carmen, Stadlbauer, Michael, Zayats, Vasilina, Krizova, Adéla, Plenk, Peter, Frischauf, Irene, Schindl, Rainer, Gruber, Hermann J., Hinterdorfer, Peter, Ettrich, Rüdiger, Romanin, Christoph, Derler, Isabella
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787804/
https://ncbi.nlm.nih.gov/pubmed/29237733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.812693
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