Communication between N terminus and loop2 tunes Orai activation

Ca(2+) release-activated Ca(2+) (CRAC) channels constitute the major Ca(2+) entry pathway into the cell. They are fully reconstituted via intermembrane coupling of the Ca(2+)-selective Orai channel and the Ca(2+)-sensing protein STIM1. In addition to the Orai C terminus, the main coupling site for S...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Fahrner, Marc, Pandey, Saurabh K., Muik, Martin, Traxler, Lukas, Butorac, Carmen, Stadlbauer, Michael, Zayats, Vasilina, Krizova, Adéla, Plenk, Peter, Frischauf, Irene, Schindl, Rainer, Gruber, Hermann J., Hinterdorfer, Peter, Ettrich, Rüdiger, Romanin, Christoph, Derler, Isabella
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787804/
https://ncbi.nlm.nih.gov/pubmed/29237733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.812693
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