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Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant
Patients with severe combined immune deficiency (SCID) suffer from defective T-cell Ca(2+) signaling. A loss of Ca(2+) entry has been linked at the molecular level to single missense mutation R91W in the store-operated Ca(2+) channel ORAI1. However, the mechanistic impact of this mutation on ORAI1 f...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708886/ https://ncbi.nlm.nih.gov/pubmed/19366689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808312200 |
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