Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating

Activation of immune cells is triggered by the Ca(2+) release-activated Ca(2+) current, which is mediated via channels of the Orai protein family. A key gating process of the three Orai channel isoforms to prevent Ca(2+) overload is fast inactivation, most pronounced in Orai3. A subsequent reactivat...

Full description

Saved in:

Bibliographic Details
Main Authors:	Frischauf, Irene, Schindl, Rainer, Bergsmann, Judith, Derler, Isabella, Fahrner, Marc, Muik, Martin, Fritsch, Reinhard, Lackner, Barbara, Groschner, Klaus, Romanin, Christoph
Format:	Artigo
Language:	Inglês
Published:	American Society for Biochemistry and Molecular Biology 2011
Subjects:	Signal Transduction
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3048740/ https://ncbi.nlm.nih.gov/pubmed/21220423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187179
Tags:	Add Tag No Tags, Be the first to tag this record!

Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating

Similar Items