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Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating
Activation of immune cells is triggered by the Ca(2+) release-activated Ca(2+) current, which is mediated via channels of the Orai protein family. A key gating process of the three Orai channel isoforms to prevent Ca(2+) overload is fast inactivation, most pronounced in Orai3. A subsequent reactivat...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048740/ https://ncbi.nlm.nih.gov/pubmed/21220423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187179 |
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