Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating

Activation of immune cells is triggered by the Ca(2+) release-activated Ca(2+) current, which is mediated via channels of the Orai protein family. A key gating process of the three Orai channel isoforms to prevent Ca(2+) overload is fast inactivation, most pronounced in Orai3. A subsequent reactivat...

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Main Authors: Frischauf, Irene, Schindl, Rainer, Bergsmann, Judith, Derler, Isabella, Fahrner, Marc, Muik, Martin, Fritsch, Reinhard, Lackner, Barbara, Groschner, Klaus, Romanin, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048740/
https://ncbi.nlm.nih.gov/pubmed/21220423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187179
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