The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

STIM1 and Orai1 represent the two molecular key components of the Ca(2+) release-activated Ca(2+) channels. Their activation involves STIM1 C terminus coupling to both the N terminus and the C terminus of Orai. Here we focused on the extended transmembrane Orai1 N-terminal (ETON, aa73–90) region, co...

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Detalhes bibliográficos
Main Authors: Derler, Isabella, Plenk, Peter, Fahrner, Marc, Muik, Martin, Jardin, Isaac, Schindl, Rainer, Gruber, Hermann J., Groschner, Klaus, Romanin, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790000/
https://ncbi.nlm.nih.gov/pubmed/23943619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.501510
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