טוען...
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
Stromal interaction molecule (STIM1) and ORAI1 are key components of the Ca(2+) release-activated Ca(2+) (CRAC) current having an important role in T-cell activation and mast cell degranulation. CRAC channel activation occurs via physical interaction of ORAI1 with STIM1 when endoplasmic reticulum Ca...
שמור ב:
| Main Authors: | , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group
2011
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101990/ https://ncbi.nlm.nih.gov/pubmed/21427704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.79 |
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