STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

Stromal interaction molecule (STIM1) and ORAI1 are key components of the Ca(2+) release-activated Ca(2+) (CRAC) current having an important role in T-cell activation and mast cell degranulation. CRAC channel activation occurs via physical interaction of ORAI1 with STIM1 when endoplasmic reticulum Ca...

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Detalhes bibliográficos
Main Authors: Muik, Martin, Fahrner, Marc, Schindl, Rainer, Stathopulos, Peter, Frischauf, Irene, Derler, Isabella, Plenk, Peter, Lackner, Barbara, Groschner, Klaus, Ikura, Mitsuhiko, Romanin, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101990/
https://ncbi.nlm.nih.gov/pubmed/21427704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.79
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