A Ca(2+) Release-activated Ca(2+) (CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca(2+)-dependent Inactivation of ORAI1 Channels

STIM1 and ORAI1, the two limiting components in the Ca(2+) release-activated Ca(2+) (CRAC) signaling cascade, have been reported to interact upon store depletion, culminating in CRAC current activation. We have recently identified a modulatory domain between amino acids 474 and 485 in the cytosolic...

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Bibliographic Details
Main Authors: Derler, Isabella, Fahrner, Marc, Muik, Martin, Lackner, Barbara, Schindl, Rainer, Groschner, Klaus, Romanin, Christoph
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757196/
https://ncbi.nlm.nih.gov/pubmed/19622747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.024083
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