Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant

Patients with severe combined immune deficiency (SCID) suffer from defective T-cell Ca(2+) signaling. A loss of Ca(2+) entry has been linked at the molecular level to single missense mutation R91W in the store-operated Ca(2+) channel ORAI1. However, the mechanistic impact of this mutation on ORAI1 f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Derler, Isabella, Fahrner, Marc, Carugo, Oliviero, Muik, Martin, Bergsmann, Judith, Schindl, Rainer, Frischauf, Irene, Eshaghi, Said, Romanin, Christoph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Mechanisms of Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708886/
https://ncbi.nlm.nih.gov/pubmed/19366689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808312200
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