Matrine in association with FD-2 stimulates F508del-cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809

Cystic fibrosis is caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the predominant mutation is termed Phe508del (F508del). Therapy for F508del-CFTR patients is based on the use of Orkambi(®), a combination of VX809 and VX770. However, though Orkambi le...

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Publicat a:Mol Med Rep
Autors principals: Marengo, Barbara, Speciale, Andrea, Senatore, Lisa, Garibaldi, Silvano, Musumeci, Francesca, Nieddu, Erika, Pollarolo, Benedetta, Pronzato, Maria Adelaide, Schenone, Silvia, Mazzei, Mauro, Domenicotti, Cinzia
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779973/
https://ncbi.nlm.nih.gov/pubmed/29039559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7736
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