Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells

BACKGROUND: P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells. Recently, a new investigational drug VX-809 has been s...

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Pubblicato in:PLoS One
Autori principali: Stanton, Bruce A., Coutermarsh, Bonita, Barnaby, Roxanna, Hogan, Deborah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446214/
https://ncbi.nlm.nih.gov/pubmed/26018799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127742
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