Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa

Cystic fibrosis (CF), the most common lethal genetic disease in Caucasians, is characterized by chronic bacterial lung infection and excessive inflammation, which lead to progressive loss of lung function and premature death. Although ivacaftor (VX-770) alone and ivacaftor in combination with lumaca...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Barnaby, Roxanna, Koeppen, Katja, Nymon, Amanda, Hampton, Thomas H., Berwin, Brent, Ashare, Alix, Stanton, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Rapid Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900360/
https://ncbi.nlm.nih.gov/pubmed/29146575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00461.2017
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