Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa

Cystic fibrosis (CF), the most common lethal genetic disease in Caucasians, is characterized by chronic bacterial lung infection and excessive inflammation, which lead to progressive loss of lung function and premature death. Although ivacaftor (VX-770) alone and ivacaftor in combination with lumaca...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Barnaby, Roxanna, Koeppen, Katja, Nymon, Amanda, Hampton, Thomas H., Berwin, Brent, Ashare, Alix, Stanton, Bruce A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2018
Témata:
Rapid Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900360/
https://ncbi.nlm.nih.gov/pubmed/29146575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00461.2017
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