Matrine in association with FD-2 stimulates F508del-cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809

Cystic fibrosis is caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the predominant mutation is termed Phe508del (F508del). Therapy for F508del-CFTR patients is based on the use of Orkambi(®), a combination of VX809 and VX770. However, though Orkambi le...

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Publicado en:Mol Med Rep
Main Authors: Marengo, Barbara, Speciale, Andrea, Senatore, Lisa, Garibaldi, Silvano, Musumeci, Francesca, Nieddu, Erika, Pollarolo, Benedetta, Pronzato, Maria Adelaide, Schenone, Silvia, Mazzei, Mauro, Domenicotti, Cinzia
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2017
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779973/
https://ncbi.nlm.nih.gov/pubmed/29039559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7736
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