Matrine in association with FD-2 stimulates F508del-cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809

Cystic fibrosis is caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the predominant mutation is termed Phe508del (F508del). Therapy for F508del-CFTR patients is based on the use of Orkambi(®), a combination of VX809 and VX770. However, though Orkambi le...

Full description

Saved in:
Bibliographic Details
Published in:Mol Med Rep
Main Authors: Marengo, Barbara, Speciale, Andrea, Senatore, Lisa, Garibaldi, Silvano, Musumeci, Francesca, Nieddu, Erika, Pollarolo, Benedetta, Pronzato, Maria Adelaide, Schenone, Silvia, Mazzei, Mauro, Domenicotti, Cinzia
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2017
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779973/
https://ncbi.nlm.nih.gov/pubmed/29039559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7736
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items