Matrine in association with FD-2 stimulates F508del-cystic fibrosis transmembrane conductance regulator activity in the presence of corrector VX809

Cystic fibrosis is caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the predominant mutation is termed Phe508del (F508del). Therapy for F508del-CFTR patients is based on the use of Orkambi(®), a combination of VX809 and VX770. However, though Orkambi le...

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Bibliografische gegevens
Gepubliceerd in:Mol Med Rep
Hoofdauteurs: Marengo, Barbara, Speciale, Andrea, Senatore, Lisa, Garibaldi, Silvano, Musumeci, Francesca, Nieddu, Erika, Pollarolo, Benedetta, Pronzato, Maria Adelaide, Schenone, Silvia, Mazzei, Mauro, Domenicotti, Cinzia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: D.A. Spandidos 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779973/
https://ncbi.nlm.nih.gov/pubmed/29039559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7736
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