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A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors

The study and development of azole-based CYP51 inhibitors is an active area of research across disciplines of biochemistry, pharmacology and infectious disease. Support of in vitro and in vivo studies require the development of robust asymmetric routes to single enantiomer products of this class of...

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Publicat a:Tetrahedron Lett
Autors principals: Lepesheva, Galina, Christov, Plamen, Sulikowski, Gary A., Kim, Kwangho
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777588/
https://ncbi.nlm.nih.gov/pubmed/29371747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2017.09.070
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