CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

CYP51 (sterol 14α-demethylase) is a cytochrome P450 enzyme essential for sterol biosynthesis and the primary target for clinical and agricultural antifungal azoles. The azoles that are currently in clinical use for systemic fungal infections represent modifications of two basic scaffolds, ketoconazo...

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Detalhes bibliográficos
Main Authors: Hargrove, Tatiana Y., Kim, Kwangho, de Nazaré Correia Soeiro, Maria, da Silva, Cristiane França, da Gama Jaen Batista, Denise, Batista, Marcos Meuser, Yazlovitskaya, Eugenia M., Waterman, Michael R., Sulikowski, Gary A., Lepesheva, Galina I.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596085/
https://ncbi.nlm.nih.gov/pubmed/23504044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2012.06.001
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