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CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds
CYP51 (sterol 14α-demethylase) is a cytochrome P450 enzyme essential for sterol biosynthesis and the primary target for clinical and agricultural antifungal azoles. The azoles that are currently in clinical use for systemic fungal infections represent modifications of two basic scaffolds, ketoconazo...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Elsevier
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596085/ https://ncbi.nlm.nih.gov/pubmed/23504044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2012.06.001 |
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