CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

CYP51 (sterol 14α-demethylase) is a cytochrome P450 enzyme essential for sterol biosynthesis and the primary target for clinical and agricultural antifungal azoles. The azoles that are currently in clinical use for systemic fungal infections represent modifications of two basic scaffolds, ketoconazo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Hargrove, Tatiana Y., Kim, Kwangho, de Nazaré Correia Soeiro, Maria, da Silva, Cristiane França, da Gama Jaen Batista, Denise, Batista, Marcos Meuser, Yazlovitskaya, Eugenia M., Waterman, Michael R., Sulikowski, Gary A., Lepesheva, Galina I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596085/
https://ncbi.nlm.nih.gov/pubmed/23504044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2012.06.001
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares