CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

CYP51 (sterol 14α-demethylase) is a cytochrome P450 enzyme essential for sterol biosynthesis and the primary target for clinical and agricultural antifungal azoles. The azoles that are currently in clinical use for systemic fungal infections represent modifications of two basic scaffolds, ketoconazo...

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Autori principali: Hargrove, Tatiana Y., Kim, Kwangho, de Nazaré Correia Soeiro, Maria, da Silva, Cristiane França, da Gama Jaen Batista, Denise, Batista, Marcos Meuser, Yazlovitskaya, Eugenia M., Waterman, Michael R., Sulikowski, Gary A., Lepesheva, Galina I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596085/
https://ncbi.nlm.nih.gov/pubmed/23504044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2012.06.001
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