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CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds
CYP51 (sterol 14α-demethylase) is a cytochrome P450 enzyme essential for sterol biosynthesis and the primary target for clinical and agricultural antifungal azoles. The azoles that are currently in clinical use for systemic fungal infections represent modifications of two basic scaffolds, ketoconazo...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596085/ https://ncbi.nlm.nih.gov/pubmed/23504044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2012.06.001 |
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