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Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients

AIMS: Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. A previous pharmacokinetic (PK) study showed that variability between patients could be partly explained by renal function and inflammatory status. The goal of this study was to co...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Franken, Linda G., de Winter, Brenda C. M., Masman, Anniek D., van Dijk, Monique, Baar, Frans P. M., Tibboel, Dick, Koch, Birgit C. P., van Gelder, Teun, Mathot, Ron A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777431/
https://ncbi.nlm.nih.gov/pubmed/28960387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13442
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