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Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect?

AIMS: Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. Because of large inter‐individual variability (IIV), however, the time it takes to achieve adequate sedation varies widely. It would therefore greatly improve clinical care if an i...

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Bibliografische gegevens
Gepubliceerd in:Br J Clin Pharmacol
Hoofdauteurs: Franken, Linda G., Masman, Anniek D., de Winter, Brenda C. M., Baar, Frans P. M., Tibboel, Dick, van Gelder, Teun, Koch, Birgit C. P., Mathot, Ron A. A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510071/
https://ncbi.nlm.nih.gov/pubmed/28177137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13259
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