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Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect?

AIMS: Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. Because of large inter‐individual variability (IIV), however, the time it takes to achieve adequate sedation varies widely. It would therefore greatly improve clinical care if an i...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Franken, Linda G., Masman, Anniek D., de Winter, Brenda C. M., Baar, Frans P. M., Tibboel, Dick, van Gelder, Teun, Koch, Birgit C. P., Mathot, Ron A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510071/
https://ncbi.nlm.nih.gov/pubmed/28177137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13259
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