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Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect?

AIMS: Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. Because of large inter‐individual variability (IIV), however, the time it takes to achieve adequate sedation varies widely. It would therefore greatly improve clinical care if an i...

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Publicado en:Br J Clin Pharmacol
Autores principales: Franken, Linda G., Masman, Anniek D., de Winter, Brenda C. M., Baar, Frans P. M., Tibboel, Dick, van Gelder, Teun, Koch, Birgit C. P., Mathot, Ron A. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510071/
https://ncbi.nlm.nih.gov/pubmed/28177137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13259
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