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Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect?

AIMS: Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. Because of large inter‐individual variability (IIV), however, the time it takes to achieve adequate sedation varies widely. It would therefore greatly improve clinical care if an i...

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Détails bibliographiques
Publié dans:Br J Clin Pharmacol
Auteurs principaux: Franken, Linda G., Masman, Anniek D., de Winter, Brenda C. M., Baar, Frans P. M., Tibboel, Dick, van Gelder, Teun, Koch, Birgit C. P., Mathot, Ron A. A.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510071/
https://ncbi.nlm.nih.gov/pubmed/28177137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13259
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