Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation

AIM: To evaluate the pharmacokinetics, pharmacodynamics, nasal tolerance and effects on sedation of a highly concentrated aqueous intranasal midazolam formulation (Nazolam) and to compare these to intravenous midazolam. METHODS: In this four‐way crossover, double‐blind, double‐dummy, randomized, pla...

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Publicat a:Br J Clin Pharmacol
Autors principals: Schrier, Lenneke, Zuiker, Rob, Merkus, Frans W. H. M., Klaassen, Erica S., Guan, Zheng, Tuk, Bert, van Gerven, Joop M. A., van der Geest, Ronald, Groeneveld, Geert Jan
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Clinical Trials
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346864/
https://ncbi.nlm.nih.gov/pubmed/27780297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13163
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