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Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients

AIMS: Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. A previous pharmacokinetic (PK) study showed that variability between patients could be partly explained by renal function and inflammatory status. The goal of this study was to co...

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Foilsithe in:Br J Clin Pharmacol
Main Authors: Franken, Linda G., de Winter, Brenda C. M., Masman, Anniek D., van Dijk, Monique, Baar, Frans P. M., Tibboel, Dick, Koch, Birgit C. P., van Gelder, Teun, Mathot, Ron A. A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777431/
https://ncbi.nlm.nih.gov/pubmed/28960387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13442
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