Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients

AIMS: Midazolam is the drug of choice for palliative sedation and is titrated to achieve the desired level of sedation. A previous pharmacokinetic (PK) study showed that variability between patients could be partly explained by renal function and inflammatory status. The goal of this study was to co...

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Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: Franken, Linda G., de Winter, Brenda C. M., Masman, Anniek D., van Dijk, Monique, Baar, Frans P. M., Tibboel, Dick, Koch, Birgit C. P., van Gelder, Teun, Mathot, Ron A. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777431/
https://ncbi.nlm.nih.gov/pubmed/28960387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13442
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