A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells

Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is mediated by the actions of two toxins, TcdA and TcdB. The toxins perturb host cell function through a multistep process of receptor binding, endocytosis, low pH–induced pore formation, and the translocation and...

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Опубликовано в: :J Biol Chem
Главные авторы: Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Zhang, Zhifen, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Melnyk, Roman A., Spiller, Benjamin W., Lacy, D. Borden
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Microbiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777265/
https://ncbi.nlm.nih.gov/pubmed/29180448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813428
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