Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase

Heightened and extended inflammation underlies the pathogenesis of many disorders, including inflammatory bowel disease, sepsis, and inflammatory arthritis. Ubiquitin networks help dictate the strength and duration of inflammatory signaling. In innate immunity, the itchy E3 ubiquitin protein ligase...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Perez, Jessica M., Chen, Yinghua, Xiao, Tsan S., Abbott, Derek W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777250/
https://ncbi.nlm.nih.gov/pubmed/29212706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000408
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