The E3 ubiquitin ligase Itch is required for B-cell development

The E3 ubiquitin ligase Itch interacts with Foxo1 and targets it for ubiquitination and degradation during follicular helper T-cell differentiation, whereas the transcription factor Foxo1 plays a critical role in B-cell development. Thus, we proposed that Itch mediates B-cell differentiation. Unexpe...

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Udgivet i:Sci Rep
Main Authors: Liu, Xiaoling, Zhang, Yu, Wei, Yinxiang, Wang, Zhiding, Zhu, Gaizhi, Fang, Ying, Zhai, Bing, Xu, Ruonan, Han, Gencheng, Chen, Guojiang, Xiao, He, Hou, Chunmei, Shen, Beifen, Li, Yan, Ma, Ning, Wang, Renxi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344599/
https://ncbi.nlm.nih.gov/pubmed/30674954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36844-9
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