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The E3 ubiquitin ligase Itch is required for B-cell development
The E3 ubiquitin ligase Itch interacts with Foxo1 and targets it for ubiquitination and degradation during follicular helper T-cell differentiation, whereas the transcription factor Foxo1 plays a critical role in B-cell development. Thus, we proposed that Itch mediates B-cell differentiation. Unexpe...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344599/ https://ncbi.nlm.nih.gov/pubmed/30674954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36844-9 |
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