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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
The E3 ubiquitin (Ub) ligase Itch is a critical regulator of T helper 2 (Th2) cytokine production through its ability to induce Ub-dependent JunB degradation. After T cell receptor engagement, Itch undergoes JNK1-mediated phosphorylation that greatly enhances its enzymatic activity. To investigate h...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413664/ https://ncbi.nlm.nih.gov/pubmed/16446428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510664103 |
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