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Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock

Hematopoietic stem cells (HSCs) maintain a quiescent state during homeostasis, but with acute infection, they exit the quiescent state to increase the output of immune cells, the so-called “emergency hematopoiesis.” However, HSCs’ response to severe infection during septic shock and the pathological...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Jianxun, Saijo, Kaoru, Skola, Dylan, Jin, Chunyu, Ma, Qi, Merkurjev, Daria, Glass, Christopher K., Rosenfeld, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777077/
https://ncbi.nlm.nih.gov/pubmed/29263096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718759114
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