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Molecular Toggle Switch of Histone Demethylase LSD1
In this issue of Molecular Cell, Laurent et al. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.
Sparad:
| I publikationen: | Mol Cell |
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| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5476831/ https://ncbi.nlm.nih.gov/pubmed/25794611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.03.007 |
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