Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation

BACKGROUND: The transcription factor GATA-2 is predominantly expressed in hematopoietic stem and progenitor cells and counteracts the erythroid-specific transcription factor GATA-1, to modulate the proliferation and differentiation of hematopoietic cells. During hematopoietic cell differentiation, G...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Guo, Yidi, Fu, Xueqi, Jin, Yue, Sun, Jing, Liu, Ye, Huo, Bo, Li, Xiang, Hu, Xin
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2015
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482369/
https://ncbi.nlm.nih.gov/pubmed/26124638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S81911
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