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LSD1 Histone Demethylase Assays and Inhibition

The lysine-specific demethylase (LSD1) is a flavin-dependent amine oxidase that selectively removes one or two methyl groups from histone H3 at the Lys4 position. Along with histone deacetylases 1 and 2, LSD1 is involved in epigenetically silencing gene expression. LSD1 has been implicated as a pote...

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Bibliografiske detaljer
Udgivet i:Methods Enzymol
Main Authors: Hayward, D., Cole, P.A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178825/
https://ncbi.nlm.nih.gov/pubmed/27372757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2016.01.020
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