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Mechanistic Analysis of a Suicide Inactivator of Histone Demethylase LSD1
The lysine-specific demethylase 1 (LSD1) is a transcriptional repressor and a flavin-dependent amine oxidase that is responsible for methyl removal from lysine-4 of histone H3. In this study, we characterize the mechanism and scope of LSD1 inhibition by a propargylamine derivatized histone H3 substr...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2531293/ https://ncbi.nlm.nih.gov/pubmed/17511474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700414b |
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