Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide analysis of its substrat...

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Bibliografiske detaljer
Main Authors: Kerenyi, Marc A, Shao, Zhen, Hsu, Yu-Jung, Guo, Guoji, Luc, Sidinh, O'Brien, Kassandra, Fujiwara, Yuko, Peng, Cong, Nguyen, Minh, Orkin, Stuart H
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2013
Fag:
Developmental Biology and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687337/
https://ncbi.nlm.nih.gov/pubmed/23795291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00633
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