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Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide analysis of its substrat...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687337/ https://ncbi.nlm.nih.gov/pubmed/23795291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00633 |
| Oznake: |
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