Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

Conventional cytotoxic chemotherapy is highly effective in certain cancers, but causes dose-limiting damage to normal proliferating cells, especially hematopoietic stem and progenitor cells (HSPCs). Serial exposure to cytotoxics causes a long-term hematopoietic compromise (‘exhaustion’), which limit...

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Udgivet i:Sci Transl Med
Main Authors: He, Shenghui, Roberts, Patrick J., Sorrentino, Jessica A., Bisi, John E., Storrie-White, Hannah, Tiessen, Renger G., Makhuli, Karenann M., Wargin, William A., Tadema, Henko, van Hoogdalem, Ewoud-Jan, Strum, Jay C., Malik, Rajesh, Sharpless, Norman E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774632/
https://ncbi.nlm.nih.gov/pubmed/28446688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal3986
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