Wild-type Kras expands and exhausts hematopoietic stem cells

Oncogenic Kras expression specifically in hematopoietic stem cells (HSCs) induces a rapidly fatal myeloproliferative neoplasm in mice, suggesting that Kras signaling plays a dominant role in normal hematopoiesis. However, such a conclusion is based on expression of an oncogenic version of Kras. Henc...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Sasine, Joshua P., Himburg, Heather A., Termini, Christina M., Roos, Martina, Tran, Evelyn, Zhao, Liman, Kan, Jenny, Li, Michelle, Zhang, Yurun, de Barros, Stéphanie C., Rao, Dinesh S., Counter, Christopher M., Chute, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124423/
https://ncbi.nlm.nih.gov/pubmed/29875320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98197
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